High-risk HPV nucleic acid detection with a 16 / 18 typing kit

Update: 2022/9/28      View:
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Introduction

High-risk HPV nucleic acid detection with a 16 / 18 typing kit

Fourteen high-risk HPV types were detected in human cervical detached cells, defining HPV16,18.

High-risk HPV nucleic acid detection with a 16 / 18 typing kit

product superiority

1 sampling, 1 experiment can test 14 high-risk types, and HPV 16 and 18 cause more than 70% cervical cancer, three results are presented once; HPV16 or HPV18 positive person recommended colposcopy, in line with ASCCP transition * guidelines;

General fluorescent PCR platform, "high throughput" detection, the result of "digital": high fluorescence quantitative PCR platform detection flux, high sensitivity, good specificity and flexible sample flux, 2 hours can be completed * can 96 specimens detection, detect only 1 specimen will not waste reagents, software automatic analysis, digital results, the results read intuitive.

High-quality product performance: * The lower detection limit is 100copy / ml, and the total consistency with the test results of HPV2 + 12 products can reach 98.51%.

Easy to operate, safe and fast, closed tube reaction, low pollution manual operation time is less than 0.5 hours. Automation: premixed liquid packaging, directly packaged to add the template can be detected; machine reading, fast detection speed, only 2.0 hours. No need to open the cover detection, greatly reduce the possibility of pollution.

Excellent performance guarantee, perfect quality control: set the reference genome β -Globin to evaluate the sample quality of the collection, the sample nucleic acid extraction quality and the PCR amplification effect, strictly monitor the whole detection process, and avoid the false negative results caused by insufficient sampling and amplification inhibition.

Widused technology platform (quantitative PCR technology): the platform can carry out HPV testing, and other clinical molecular diagnostic projects and scientific research projects.

Clinical significance

Extensive evidence suggests that persistent infection with the same, high-risk type of HPV is essential for cervical carcinogenesis. WHO and IRAC have identified 14 high-risk HPV types associated with cervical cancer, mainly causing cervical intraepithelial intermediate and highly neoplasia (CINII, CTNIII) and cervical invasive squamous cell carcinoma. According to studies from around the world, the infection rate of HPV16 / 18 in 14 high-risk HPV types * causes about 70% of cervical cancer. In 2015, the ASCCP / SGO interim clinical guidelines recommended that high-risk HPV2 + 12 should be used alone for primary screening of cervical cancer, and HPV16 or HPV18 oscopy was performed directly, as follows:

1. As HPV is the primary screening method, H P V is screened every 3 years. For HPV16 and H P V type 18 positive, direct referred to colposcopy;

2. For the other 12 high-risk HPV positive, conduct cytology test, refer to colposcopy; if the cytology is negative, follow-up for 12 months;

3. If the 14 high-risk HPV types are negative, they can undergo routine screening every 3 years;

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